Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study
Identifieur interne : 003086 ( Main/Exploration ); précédent : 003085; suivant : 003087Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study
Auteurs : N. E. Maher [États-Unis, Canada, Allemagne, Italie] ; L. I. Golbe ; A. M. Lazzarini ; M. H. Mark ; L. J. Currie ; G. F. Wooten ; M. Saint-Hilaire ; J. B. Wilk ; J. Volcjak ; J. E. Maher ; R. G. Feldman ; M. Guttman ; M. Lew ; S. Schuman ; O. Suchowersky ; A. L. Lafontaine ; N. Labelle ; P. Vieregge ; P. P. Pramstaller ; C. Klein ; J. Hubble ; C. Reider ; J. Growdon ; R. Watts ; E. Montgomery ; K. Baker ; C. Singer ; M. Stacy ; R. H. MyersSource :
- Neurology [ 0028-3878 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Objective: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. Methods: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. Results: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (p = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, p = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). Conclusions: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease.
Affiliations:
- Allemagne, Canada, Italie, États-Unis
- Alberta, Californie, Massachusetts, Ontario
- Boston, Calgary, Los Angeles, Toronto
- Université de Calgary, Université de Californie du Sud, Université de Toronto
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Maher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>MA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>MA</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1><s2>New Brunswick</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Virginia Health System</s1><s2>Charlottesville</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Division of Neurology, Department of Medicine, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Neurology, University of Southern California</s1><s2>Los Angeles</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Medical University of Lübeck</s1><s3>DEU</s3></inist:fA14><country>Allemagne</country><wicri:noRegion>Medical University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, Medical University of Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, General Regional Hospital Bolzano</s1><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Department of Neurology, General Regional Hospital Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, Ohio State University</s1><s2>Columbus</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Neurology Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, GA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>OH</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>OH</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, University of Miami</s1><s2>FL</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>FL</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Barrow Clinic</s1><s2>Phoenix, AZ</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Phoenix, AZ</wicri:noRegion></affiliation></author><author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. 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E." last="Maher">N. E. Maher</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1><s2>MA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>MA</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1><s2>New Brunswick</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>New Brunswick</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of Virginia Health System</s1><s2>Charlottesville</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Division of Neurology, Department of Medicine, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Neurology, University of Southern California</s1><s2>Los Angeles</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1><s2>Alberta</s2><s3>CAN</s3></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Medical University of Lübeck</s1><s3>DEU</s3></inist:fA14><country>Allemagne</country><wicri:noRegion>Medical University of Lübeck</wicri:noRegion><wicri:noRegion>Department of Neurology, Medical University of Lübeck</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Neurology, General Regional Hospital Bolzano</s1><s3>ITA</s3></inist:fA14><country>Italie</country><wicri:noRegion>Department of Neurology, General Regional Hospital Bolzano</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Neurology, Ohio State University</s1><s2>Columbus</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Neurology Massachusetts General Hospital, Harvard Medical School</s1><s2>Boston</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Neurology, Emory University</s1><s2>Atlanta, GA</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Atlanta, GA</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1><s2>OH</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>OH</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurology, University of Miami</s1><s2>FL</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>FL</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Neurology, Barrow Clinic</s1><s2>Phoenix, AZ</s2><s3>USA</s3></inist:fA14><country>États-Unis</country><wicri:noRegion>Phoenix, AZ</wicri:noRegion></affiliation></author><author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name></author><author><name sortKey="Lazzarini, A M" sort="Lazzarini, A M" uniqKey="Lazzarini A" first="A. M." last="Lazzarini">A. M. Lazzarini</name></author><author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name></author><author><name sortKey="Currie, L J" sort="Currie, L J" uniqKey="Currie L" first="L. J." last="Currie">L. J. Currie</name></author><author><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name></author><author><name sortKey="Saint Hilaire, M" sort="Saint Hilaire, M" uniqKey="Saint Hilaire M" first="M." last="Saint-Hilaire">M. Saint-Hilaire</name></author><author><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name></author><author><name sortKey="Volcjak, J" sort="Volcjak, J" uniqKey="Volcjak J" first="J." last="Volcjak">J. Volcjak</name></author><author><name sortKey="Maher, J E" sort="Maher, J E" uniqKey="Maher J" first="J. E." last="Maher">J. E. Maher</name></author><author><name sortKey="Feldman, R G" sort="Feldman, R G" uniqKey="Feldman R" first="R. G." last="Feldman">R. G. Feldman</name></author><author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name></author><author><name sortKey="Lew, M" sort="Lew, M" uniqKey="Lew M" first="M." last="Lew">M. Lew</name></author><author><name sortKey="Schuman, S" sort="Schuman, S" uniqKey="Schuman S" first="S." last="Schuman">S. Schuman</name></author><author><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name></author><author><name sortKey="Lafontaine, A L" sort="Lafontaine, A L" uniqKey="Lafontaine A" first="A. L." last="Lafontaine">A. L. Lafontaine</name></author><author><name sortKey="Labelle, N" sort="Labelle, N" uniqKey="Labelle N" first="N." last="Labelle">N. Labelle</name></author><author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name></author><author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name></author><author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name></author><author><name sortKey="Hubble, J" sort="Hubble, J" uniqKey="Hubble J" first="J." last="Hubble">J. Hubble</name></author><author><name sortKey="Reider, C" sort="Reider, C" uniqKey="Reider C" first="C." last="Reider">C. Reider</name></author><author><name sortKey="Growdon, J" sort="Growdon, J" uniqKey="Growdon J" first="J." last="Growdon">J. Growdon</name></author><author><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name></author><author><name sortKey="Montgomery, E" sort="Montgomery, E" uniqKey="Montgomery E" first="E." last="Montgomery">E. Montgomery</name></author><author><name sortKey="Baker, K" sort="Baker, K" uniqKey="Baker K" first="K." last="Baker">K. Baker</name></author><author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name></author><author><name sortKey="Stacy, M" sort="Stacy, M" uniqKey="Stacy M" first="M." last="Stacy">M. Stacy</name></author><author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of onset</term><term>Aggregation</term><term>Epidemiology</term><term>Genetic determinism</term><term>Human</term><term>Parkinson disease</term><term>Phenotype</term><term>Risk factor</term><term>Sibling</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Age apparition</term><term>Agrégation</term><term>Phénotype</term><term>Déterminisme génétique</term><term>Epidémiologie</term><term>Fratrie</term><term>Facteur risque</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To examine patterns of familial aggregation and factors influencing onset age in a sample of siblings with PD. Methods: Sibling pairs (n = 203) with PD were collected as part of the GenePD study. Standardized family history, medical history, and risk factor data were collected and analyzed. Results: The mean age at onset was 61.4 years and did not differ according to sex, exposure to coffee, alcohol, or pesticides. Head trauma was associated with younger onset (p = 0.03) and multivitamin use with later onset (p = 0.007). Age at onset correlation between sibling pairs was significant (r = 0.56, p = 0.001) and was larger than the correlation in year of onset (r = 0.29). The mean difference in onset age between siblings was 8.7 years (range, 0 to 30 years). Female sex was associated with increased frequency of relatives with PD. The frequency of affected parents (7.0%) and siblings (5.1%) was increased when compared with frequency in spouses (2.0%). Conclusions: The greater similarity for age at onset than for year of onset in sibling pairs with PD, together with increased risk for biological relatives over spouses of cases, supports a genetic component for PD. Risk to siblings in this series is increased over that seen in random series of PD cases; however, patients in this sample have similar ages at onset and sex distribution as seen for PD generally. These analyses suggest that factors influencing penetrance are critical to the understanding of this disease.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Italie</li><li>États-Unis</li></country><region><li>Alberta</li><li>Californie</li><li>Massachusetts</li><li>Ontario</li></region><settlement><li>Boston</li><li>Calgary</li><li>Los Angeles</li><li>Toronto</li></settlement><orgName><li>Université de Calgary</li><li>Université de Californie du Sud</li><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Baker, K" sort="Baker, K" uniqKey="Baker K" first="K." last="Baker">K. Baker</name><name sortKey="Currie, L J" sort="Currie, L J" uniqKey="Currie L" first="L. J." last="Currie">L. J. Currie</name><name sortKey="Feldman, R G" sort="Feldman, R G" uniqKey="Feldman R" first="R. G." last="Feldman">R. G. Feldman</name><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name><name sortKey="Growdon, J" sort="Growdon, J" uniqKey="Growdon J" first="J." last="Growdon">J. Growdon</name><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name><name sortKey="Hubble, J" sort="Hubble, J" uniqKey="Hubble J" first="J." last="Hubble">J. Hubble</name><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name><name sortKey="Labelle, N" sort="Labelle, N" uniqKey="Labelle N" first="N." last="Labelle">N. Labelle</name><name sortKey="Lafontaine, A L" sort="Lafontaine, A L" uniqKey="Lafontaine A" first="A. L." last="Lafontaine">A. L. Lafontaine</name><name sortKey="Lazzarini, A M" sort="Lazzarini, A M" uniqKey="Lazzarini A" first="A. M." last="Lazzarini">A. M. Lazzarini</name><name sortKey="Lew, M" sort="Lew, M" uniqKey="Lew M" first="M." last="Lew">M. Lew</name><name sortKey="Maher, J E" sort="Maher, J E" uniqKey="Maher J" first="J. E." last="Maher">J. E. Maher</name><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name><name sortKey="Montgomery, E" sort="Montgomery, E" uniqKey="Montgomery E" first="E." last="Montgomery">E. Montgomery</name><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name><name sortKey="Reider, C" sort="Reider, C" uniqKey="Reider C" first="C." last="Reider">C. Reider</name><name sortKey="Saint Hilaire, M" sort="Saint Hilaire, M" uniqKey="Saint Hilaire M" first="M." last="Saint-Hilaire">M. Saint-Hilaire</name><name sortKey="Schuman, S" sort="Schuman, S" uniqKey="Schuman S" first="S." last="Schuman">S. Schuman</name><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name><name sortKey="Stacy, M" sort="Stacy, M" uniqKey="Stacy M" first="M." last="Stacy">M. Stacy</name><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name><name sortKey="Volcjak, J" sort="Volcjak, J" uniqKey="Volcjak J" first="J." last="Volcjak">J. Volcjak</name><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name></noRegion><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name></country><country name="Canada"><region name="Ontario"><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name></region><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name></country><country name="Allemagne"><noRegion><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Maher, N E" sort="Maher, N E" uniqKey="Maher N" first="N. E." last="Maher">N. E. Maher</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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